Yankees Opening Day 2025 Schedule. Will open the season at home on 3/27 vs. M ajor league baseball released its schedule for the 2025 season, and the yankees will be opening their their campaign with an interleague matchup.

Depending on where in the world you are reading this story from, it may not look like baseball season outside your window, but opening day will be here before you know it. Things will get started at 3 p.m.